The New 'Knowledge Speak': the implications of contested definitions of knowledge and information

This paper presents a critique of notions of information and knowledge found in the management literature and amongst proponents of 'knowledge management' (Davenport and Prusak 2000) interviewed in the course of a study of changing operations of the Federal Government of Canada vis a vis the 'knowledge-based economy' as it is found in Canada (Shields, Taborsky, Jones, and O'Hara 2000). Interviews with a range of Federal Government Departments and Agencies on a number of topics including knowledge management were conducted throughout the Summer of 2000. During these interviews a number of competing definitions and numerous misunderstandings of the relationship between knowledge and information emerged. We will distinguish and contrast these with definitions derived from semiotic and information science frameworks. We argue for the importance of the collective and processual nature of knowledge. Our conclusions allow us to specify the shortcomings of existing knowledge management approaches and to identify a necessary and specific focus for future knowledge initiatives in organizations

Innovation, Design and the Virtual

This article outlines a case for architects and designers to bemore involved in discussions of innovation in constructionand engineering and more generally in discussions of virtualitiesincluding style, community, market, and brand which characterizewealth creation in knowledge societies. The virtual is a strategic topicwhich is a common aspect of both design and innovationand is approachable through design methodologies

Introduction. Going Beyond Melt and Cryodispossession

Non peer reviewe

A Comparison of Techniques for Decomposing Surface Electromyography Signals During High-Intensity Contractions a Preliminary Analysis

Advancements in surface electromyography (sEMG) have led to discrepancies in identification of high-threshold motor units (MU) following signal decomposition PURPOSE: To examine the differences in MU firing behaviors recorded from two separate sEMG sensors following respective decomposition analysis. METHODS: Following 2 maximal voluntary contractions (MVC), ten (23 ± 3 yrs.; 178.64 ± 5.82 cm; 177.8 ± 17.37 kg) lower body resistance trained males performed a 10 sec submaximal (50%) isometric ramp contraction of the knee extension exercise. Signals were recorded from the vastus lateralis and separately decomposed into their constituent MU action potential trains, then further validated for subsequent analysis of firing behaviors. The slope and y-intercept were calculated between recruitment threshold versus mean firing rate (RT/MFR). Two separate paired samples t test were used to compare differences in regression coefficients for RT/MFR relationships between sensors, and differences in RTs of validated MUs during 50%MVC. RESULTS: There were significant differences in RT/MFR coefficients between the two sensors (p\u3c 0.05), as well as, respective RTs from the identified MUs (pCONCLUSION: We are uncertain as to what led to the differences between the two sEMG systems (decomposition algorithms, validation techniques, application area, etc). It is feasible that the substantial difference in yield (i.e. number of validated MUs), possibly due to different validation criteria, affected the outcomes. Thus, further studies should examine the effects of manual editing validation process on the end results

Experimental Confirmation of a Predicted Porous Hydrogen‐Bonded Organic Framework

AbstractHydrogen‐bonded organic frameworks (HOFs) with low densities and high porosities are rare and challenging to design because most molecules have a strong energetic preference for close packing. Crystal structure prediction (CSP) can rank the crystal packings available to an organic molecule based on their relative lattice energies. This has become a powerful tool for the a priori design of porous molecular crystals. Previously, we combined CSP with structure‐property predictions to generate energy‐structure‐function (ESF) maps for a series of triptycene‐based molecules with quinoxaline groups. From these ESF maps, triptycene trisquinoxalinedione (TH5) was predicted to form a previously unknown low‐energy HOF (TH5‐A) with a remarkably low density of 0.374 g cm−3 and three‐dimensional (3D) pores. Here, we demonstrate the reliability of those ESF maps by discovering this TH5‐A polymorph experimentally. This material has a high accessible surface area of 3,284 m2 g−1, as measured by nitrogen adsorption, making it one of the most porous HOFs reported to date.</jats:p

Patterns of postmeal insulin secretion in individuals with sulfonylurea- treated KCNJ11 neonatal diabetes show predominance of non- KATP- channel pathways

Insulin secretion in sulfonylurea-treated KCNJ11 permanent neonatal diabetes mellitus (PNDM) is thought to be mediated predominantly through amplifying non-KATP-channel pathways such as incretins. Affected individuals report symptoms of postprandial hypoglycemia after eating protein/fat-rich foods. We aimed to assess the physiological response to carbohydrate and protein/fat in people with sulfonylurea-treated KCNJ11 PNDM.This article is freely available via Open Access. Click on the Publisher URL to access the full-text via the publisher's site

Experimental Confirmation of a Predicted Porous Hydrogen-bonded Organic Framework

Hydrogen-bonded organic frameworks (HOFs) with low densities and high porosities are rare and challenging to design because most molecules have a strong energetic preference for close packing. Crystal structure prediction (CSP) can rank the crystal packings available to an organic molecule based on their relative lattice energies. This has become a powerful tool for the a priori design of porous molecular crystals. Previously, we combined CSP with structure-property predictions to generate energy-structure-function (ESF) maps for a series of triptycene-based molecules with quinoxaline groups. From these ESF maps, triptycene trisquinoxalinedione (TH5) was predicted to form a previously unknown low-energy HOF (TH5-A) with a remarkably low density of 0.374 g cm-3 and three-dimensional (3-D) pores. Here, we demonstrate the reliability of those ESF maps by discovering this TH5-A polymorph experimentally. This material has a high accessible surface area of 3,284 m2 g-1, as measured by nitrogen adsorption, making it one of the most porous HOFs reported to date